2,3-bisphosphoglycerate (BPG) is an inhibitor of hemoglobin (Hb). Answer the following questions about BPG and its regulation of oxygen binding:

2,3-bisphosphoglycerate (BPG) is an inhibitor of

hemoglobin (Hb). Answer the following questions about BPG and its regulation of oxygen binding:

d) Imagine that you’re studying a mutant Hb that you made in the lab that decreases the affinity for

BPG while otherwise not affecting the usual T-R equilibrium.

i) Draw a standard O2 binding curve for wild-type Hb and indicate how the curve for the mutant

Hb would be shifted relative to wild-type Hb.

ii) Briefly explain how the mutation would affect O2 binding and release in both the lungs and

peripheral tissue.

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