Cohesin mediates transcriptional insulation by CCCTC-binding factor

In proliferating cells, cohesin complexes physically connect replicated DNA molecules (‘sister chromatids’) from S phase until the
subsequent anaphase of mitosis or meiosis. This sister-chromatid
cohesion is essential for chromosome segregation and for DNA
damage repair. Cohesin is composed of four core subunits, called
SMC1, SMC3, SCC1 (also known as MDC1 and RAD21) and SCC3
(also known as SA2 and STAG2)
. These proteins have been proposed to mediate cohesion by embracing sister chromatids as a ring


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