In the citric acid cycle, the dehydrogenation of malate into oxaloacetate is quite unfavorable in terms of energy.

In the citric acid cycle, the dehydrogenation of malate into oxaloacetate is quite unfavorable in terms of energy. Incoming acetyl Co-A reacts with oxaloacetate to form citrate via citrate synthase, thereby depleting oxaloacetate. If the conversion of malate into oxaloacetate is so unfavorable, then why does it happen?

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