NSC2500 Pharmacology And Pathophysiology In Health

NSC2500 Pharmacology And Pathophysiology In Health

Question:

Graves’ disease is caused by the production of autoantibodies to the TSH receptor. These antibodies interact with the TSH receptor to stimulate the thyroid gland in a similar manner to TSH. The antibodies are not subject to negative feedback.

Which of the sets of clinical laboratory values below would indicate Graves’ disease? Explain/defend your answer. Serum thyroxine ug/100mL 6 1.5 Patient B 16 0.75 Patient C 2.5 20 Patient D 12 10 Normal 4 – 11 1.5 – 6

 Serum thyroxine      ug/100mLSerum TSH      uIU*/mL
Patient A61.5
Patient B160.75
Patient C2.520
Patient D1210
NORMAL 4-111.5-6

*IU = International Units – a standard way of quantifying TSH amounts

NSC2500 Pharmacology And Pathophysiology In Health

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