Two graduate students are arguing about what transgenic mouse to make. One wants to make a mouse (A) where SGTL2 would only be active when insulin goes up, that is, SGLT2 would not work when insulin is low or normal (for fasting glucose levels) but would become active when insulin increased above the normal fasting levels. (This mutation would change SGLT2 so SGTL2 would become insulin sensitive). The other graduate student wants to make a mouse (B) where SGLT2 would only be active when glucagon goes up, that is, SGLT2 would not work when glucagon is low but would become active when glucagon increased above the normal levels. Compare what happens to blood sugar in mouse A versus in mouse B. Discuss both what happens with a fasting mouse and one that drinks some soda (even though mice can’t use straws.
For mouse A, what happens to blood sugar level when it is fasting? When it drink glucose water?
For mouse B, what happens when it is fasting? When mouse B drinks glucose water? You are to assume that SGLT is operating as prescribed in the problem.